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AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

These local effects typically resolve rapidly and rarely require intervention beyond injection site rotation

Ferroptotic cancer cells are more likely to provoke tumor-specific immune responses, enhancing the efficacy of immune checkpoint inhibitors (ICIs) (80,81)

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To illustrate the success of the application and the way of application efficacy, it may be instructive to mention the noted effect in the recovery of the transected sciatic nerve injury (providing the efficacy of the once intraperitoneal, intragastric application much like the application into the tube with inserted nerve stumps) (Wang et al., 2019)