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Of note, unlike carbonyl scavengers that target only a single line of defense, NRF2 regulates genes across all three defense lines, including those encoding antioxidant enzymes, RLA-detoxifying enzymes, and components of the 20S proteasome and lysosome, such as Proteasome Subunit -Type 5 (PSMB5), PA28, and Sequestosome-1 (p62) (216223)

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Fillers injected below the surface of the skin enhance contours, soften facial features, and plump lips

Similar approaches with minor modifications were applied by Iserman et al

PLoS ONE 3 , e3942 (2008)