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Taken together, compound 1D228 may be a promising candidate for the next generation of c-Met and TRK inhibitors for cancer treatment, and offers a novel potential treatment strategy for cancer patients with abnormal expressions of c-Met or NTRK, or simultaneous of them

They're shallow shots, so you need a short and small needle

Repeated exposure to environmental conditions may introduce variability and affect molecular integrity

Franco, M

MET can upregulate the expression of efflux transporters in the cell membrane, thus reducing the intracellular concentration of the chemotherapeutic agent