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Even successful CAR T-cell therapy may fail to reverse established organ damage in autoimmune diseases, as demonstrated by SLE-related glomerulosclerosis, pulmonary fibrosis in systemic sclerosis, exocrine gland fibrosis in Sjgrens syndrome, and demyelinating lesions in multiple sclerosis

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There are also hybrid yeast models in which functional interactions between two proteins, such as -syn and synphilin-1, are studied

By directly testing whether activated neurons primarily oxidize astrocyte-derived lactate versus other substrates, and by accurately accounting for all sources of oxygen (vascular and extravascular), such approaches could provide definitive evidence to reconcile the conflicting models (Tietze, 1969