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These substances can interact with membranes, bind cholesterol, and alter lipid metabolism because they are amphipathic (104)

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doi: 10.1016/j.mehy.2011.03.030 96 LacerdaEMGeraghtyKKingdonCCPallaLNaculL

doi: 10.1016/j.cell.2004.07.013 145 HofsethLJSinghUPSinghNPNagarkattiMNagarkattiPS

91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways