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20 As the rapid rise in atmospheric O 2 presented a new challenge for cellular energetics, single-celled life forms were forced to adapt, including giving rise to multicellular life

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CD4+ T helper cells stimulated with Dynabeads CD3/CD28 will differentiate into different T helper subsets, depending on the cytokines added during in vitro culture conditions

ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)