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Induction of ferroptosis by erastin, C dot, or FAC and BSO leads to its dissemination to neighboring cells through an iron and lipid peroxide-dependent mechanism, whereas the GPX4 inhibitor ML162 fails to transmit the ferroptosis signal to adjacent cells

Intriguingly, a competitive relationship between the homologues CHAC1 and CHAC2 was observed in human embryonic stem cells (hESCs), where they play opposing roles in maintaining cellular GSH levels and regulating differentiation ( 2.4.2 CHAC1 in neuroprotection and organ injury Similar to its role in stem cell fate, CHAC1/BOTCH exhibits a dual function in regulating neuroprotection and inflammation following neuronal damage and organ injury

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Additionally, Principal Coordinates Analysis (PCoA) demonstrated major differences in the composition of the microbiota between these two groups, further emphasizing the modifications imposed by ATX on the intestinal microbiota of the MCAO rats (Fig

After 30 mins exposure, zoospores survival was determined by observing movement under a microscope (a total loss of motility was considered as indicative of zoospore death)