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(Neelakantan et al., 2018)

[DOI] [PubMed] [Google Scholar] 32.Akiyama M, Sawamura D, Nomura Y, Sugawara M, Shimizu H

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Given the inconsistent nature of these findings across real-world studies, there is still much to understand about the potential effect of DOR on weight in real-world settings

Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling