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10.7717/peerj.2702 86 McLearyF.DavisA.RudrawarS.PerkinsA.Anoopkumar-DukieS

In response, this review highlights the current state of understanding of the nose-to-brain drug delivery pathway and how both biological and clinical barriers to drug transport using the pathway can been addressed, as illustrated by demonstrations of how currently approved intranasal sprays leverage these pathways to enable the design of successful therapies

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