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576,577 Activation of the EMT program enables tumor cells to resist the therapeutic agents, which is consistent with the attribute of CSCs

McIntosh | Bradley

2.2.2 Amino acid metabolism Mounting studies indicate that cystine uptake via System Xc is crucial for maintaining glutathione (GSH) levels and inhibiting ferroptosis ( (a special cystine/glutamate transporter) exchanges intracellular glutamate for extracellular cystine in a 1:1 ratio ( transport may be inhibited by elevated extracellular glutamate levels