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In cases where blood vessels malfunction, like in DR, FSP1 may play a role in controlling the growth of extra blood vessels and the formation of tough scar tissue by communicating with growth factors and the cell surface receptors, which in turn affects how the extracellular matrix changes and the series of events that lead to new blood vessel formation

(91) demonstrated that nuciferine inhibits ferroptosis via the SOX2-mediated SLC7A11/GPX4 signaling axis, thereby protecting ovarian granulosa cells from androgen-induced damage

de Freitas, Maria E

10.1016/j.fct.2016.11.032 Food Chem Toxicol

These results were consistent with Ki-67 staining, HE staining and TUNEL assay, which showed that treatment with the NAC and NAC + BSO resulted in the lower level of proliferative capacity, higher level of necrotic lesions and higher apoptosis rate, respectively (Fig