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(22) showed recently that L-carnitine supplementation promoted improvements in several parameters, including O2 saturation, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), alkaline phosphatase (ALP) activity, lactate dehydrogenase (LDH), and serum creatine phosphokinase (CPK) when compared to the intervention group

It is also independently associated with abnormal lipid metabolism as well as an increased risk of cardiovascular and cerebrovascular disease compared to E3 and E2 alleles (Belloy et al., 2019

Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, et al

However, the real effects of L-carnitine supplementation, taking into account its above-mentioned positive and possibly negative properties ( via TMAO), on the process of atherosclerosis and atheroma plaque merit further investigations