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Induced pluripotent stem cells (iPSCs) generated by reprogramming human somatic cells have been broadly used since 2008 and afford an efficient model system for disease modeling, toxicity screens, and screening for novel therapeutics because of their genetic relevance to individuals with the disease [12,13,14,15,16]

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Animals were randomized into 4 groups (16 rats each) and further allocated into 2 cohorts, one for neuronal tracing (n = 6/group) and the other for functional evaluation (n = 10/group)

DOX: 4 mg/kg

There is evidence that the depletion of SOD, a mitochondrial free radical scavenger, in connective tissue leads to the acceleration of skin ageing [123]