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The choice of procedure is guided by the joint involved, severity of structural damage, patient age, activity level, and comorbidities (Table 3) (Katz et al., 2010

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Methods/Design The systematic review protocol follows the recommendations of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocol (PRISMA-P) [16], and to ensure the quality of the protocol, the PRISMA-P checklist was completed (S1 Checklist)

2 YOUR LABS Following the initial consultation, we will have you complete some simple lab work at our center or diagnostic center near you