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Phytochemicals with high binding affinity to the inflammatory or oxidative stress related target in silico are often correlated with lower levels of cytokines, reduced of lipid peroxidation and increased levels of antioxidant enzyme activity in animal wound models

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This suggests that Nrf2 plays an essential role in down-regulating cyclin D1 and promoting cell cycle arrest at excessive levels of oxidative stress (Mrton et al., 2018)

& LeCouter, J