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This model is substantiated by Wang et al., who characterized a metabolic subtype-specific fibroblast cluster (SFRP2 + CAFs) in colorectal cancer

However, in the evaluation of adverse reactions, the incidence of neutropenia in Japanese patients was higher than that in Western patients (76, 77) Thus, a randomized, multicentre, double-blind phase 3 RAINBOW-Asia trial (78, 79) (a bridging study similar to RAINBOW) was initiated, in which patients were randomized to receive ramucirumab plus paclitaxel (n=294) or placebo plus paclitaxel (n=146), the primary outcome was (mPFS 4.14 months vs 3.15 months, mOS 8.71 months vs 7.92 months), and the most common adverse reaction was also decreased neutrophil count (54% vs 39%)

Additionally, UA promotes skeletal muscle angiogenesis through modulation of the silent information regulator 1 and peroxisome proliferator-activated receptor-gamma coactivator-1-alpha signaling pathways, resulting in increased capillary density and improved muscular endurance (8)

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(41) have recently discussed the relationships of these proteins and suggested that they should be classified into two types, which they termed farinins and purinins