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The rodA gene encodes a small hydrophobic cysteine-rich polypeptide and the mutant strains for this gene showed high sensitivity to destruction by alveolar macrophages but were as virulent as the wild strain.215,274 However, the rodA strain produced smaller lung lesions and weaker inflammatory response than the reference strain.252 On the other hand, the rodB mutant did not show high sensitivity to killing by alveolar macrophages and did not lose their virulence.215 Another surface component of the fungi that has been associated with virulence is melanin, a pigment that protects the integrity of the genome in conidia from ultraviolet light, enzymatic lysis, and oxidation