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Hence, a possible adipo-insular axis is reasonable, where the IGF system may play a significant role (43)

Finally, ceramide can follow four major catabolic pathways: (1) phosphorylated by the ceramide kinase (CERK) to form ceramide-1-phosphate (C1P), (2) incorporated into sphingomyelin-by-sphingomyelin synthase (SMS) activity, (3) or into glucosylceramide by the activation of glucosylceramide synthases (GCS), leading to the generation of complex SLs like cerebrosides, gangliosides, sulfatides and globosides

Table 2 summarizes the main types of LSDs that invade the CNS according to the accumulated general substrate

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[DOI] [Google Scholar] 201.Goslar J., Hilczer B., Smogr H