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Funding This work was supported by the Postdoctoral Innovation Practice Base of the First Affiliated Hospital of Nanchang University (grant 338937), the Jiangxi Provincial Young Talents Project (grant 20204BCJ23016), the National Natural Science Foundation of China (grants 82202869, 82260491, 82160459, 82160469,82360584), the Jiangxi Province Double Thousand Program (grant jxsq2023201108), Key Projects of Jiangxi Province (grant 20232ACB206044), the Science and Technology Department of Jiangxi Province (grant 20202BABL216050), and the Jiangxi Provincial Natural Science Foundation (grant 20232BAB216087 and 20224BAB216008)

A 0.3 mL, 31G, 5/16 inch syringe is not the same product as a 1 mL, 29G, 1/2 inch syringe

At 1 h after administration, [ 3 H]proline accounted for 86.65% of the plasma radioactive components

Both compounds bind to plasma protein, then become concentrated in the brain (up to 50 times more concentrated)

Reconstitution Guidelines Standard peptide preparation procedures should be followed when preparing Cagrilintide solutions for laboratory use