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Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer

Younessi, P., and A

448 When implanted alongside GBM stem cells, these engineered cells significantly inhibited tumor growth in vivo

10.1067/j.cpradiol.2011.01.003 9

Both the PI3K/Akt and Ras/MAPK signaling will phosphorylate the proapoptotic protein BAD, causing inactivation due to cytoplasmic sequestration, which leads to enhanced platinum resistance by blocking apoptosis [114]