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If it lasts more than a week or severe, then inform your doctor

"Reversal of obesity by targeted ablation of adipose tissue." Nature Medicine 10.6 (2004): 625-632

At the end of the day, as long as you're getting this essential nutrient into your system, that's all that matters

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observed a decrease in B12 and folate levels and an increase in homocysteine levels in relapsingremitting MS patients [124]