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IGF-I and -II had actions through the type 1 IGF receptor (IGF1R) demonstrated by Igf1r ko animals with 45% of wild type birth weight and no further effect when crossed with Igf1 ko animals

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Studies published in Biochemical Pharmacology show that NNMT expression increases significantly with aging in skeletal muscle tissue and correlates with impaired muscle stem cell function and reduced regenerative capacity