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A recent study published in MDPI investigated L-theanine's ability to protect against subchronic neuroinflammation induced by lipopolysaccharide (LPS)

Thats because clinical studies arent extensive enough to confidently state its benefits

In contrast, curcumin was not detected in the liver tissue of patients with liver metastases of colorectal cancer after the same oral dose of curcumin (11), suggesting that oral curcumin administration may not effectively deliver curcumin to tissues outside the gastrointestinal tract

Seppen J, Bosma PJ, Goldhoorn BG, Bakker CT, Chowdhury JR, Chowdhury NR et al

This anti-biofilm property is beneficial in preventing dental plaque formation and in disrupting mature plaques that cause gingivitis and periodontitis