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Sikiric, P., Drmic, D., Sever, M., Klicek, R., Blagaic, A., Tvrdei, A., Kralj, T., Kovac, K., Vukojevi, J., Siroglavi, M., Gojkovic, S., Krezic, I., Pavlov, K., Rasic, D., Mirkovic, I., Kokot, A., krti, A., & Seiwerth, S

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Epitalon mechanism is better understood at the enzymatic level (AANAT upregulation, pCREB activation) but the full picture of how it achieves tissue-specific pineal protection remains unclear

The paper concludes by proposing a unified mechanism whereby BBB dysfunction contributes to neurodegenerative disorders, highlights potential BBB-focused therapeutic strategies and targets, and outlines lessons learned and future research directions