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Many therapies that perform exceptionally well in animals ultimately fail to deliver the same benefits in humans

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This is not an exhaustive list, but it includes those that have the most evidence and historical use supporting benefit

Semaglutide, by contrast, is a glucagon-like peptide-1 (GLP-1) receptor agonist that slows gastric emptying, suppresses appetite centrally via hypothalamic signalling, and modulates insulin secretion in response to glucose

Readers are encouraged to read these articles for further background on how ROS are generated during respiration and what defences our body has against them.) More specifically, GPx1 neutralises and protects against damage from one ROS in particular hydrogen peroxide (H2O2)