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An intact JAK2-STAT5b signaling pathway is essential for GH stimulation of IGF-1 gene expression

10.1111/bph.16009 49 HuL.TanJ.YangX.TanH.XuX.YouM.et al (2016)

Salinity-induced ionic and osmotic instability results in increased generation of reactive oxygen species and methylglyoxal, leading to oxidative and carbonyl stress

However, superoxide and hydrogen peroxide play a physiological role in signaling molecules and regulate apoptosis, cell proliferation, and cell differentiation 18,19