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A central driver of the debilitating cognitive symptoms experienced by these patients is chronic neuroinflammation

Lee J-M, Calkins MJ, Chan K, Kan YW, Johnson JA

Futhermore, Zn 2+ is involved in an inhibitory competition with Cu 2+ (or Fe 3+ ) for the binding to A [205, 230]

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120 In myeloid cell-specific SIRT1 knockout mice, lipid toxicity or LPS stimulation induced more severe hepatic inflammation, elevated pro-inflammatory cytokine levels, and enhanced M1 macrophage polarization, highlighting the critical role of SIRT1 in preserving immune balance