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Dupradeau, F

doi: 10.1074/jbc.M805711200

Another aspect of the present invention is a carrier-linked prodrug comprising a biodegradable hydrogel of the present invention as carrier, wherein a number of permanent linkages of the backbone moieties exist with a transient prodrug linker to which a biologically active moiety is covalently attached

The clinical experts have suggested a series of metabolic alternations that in concentration would explain the poor outcome that an ICU patient with this depletion present (Figure 8)