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Acknowledgements This work is dedicated to the memory of Prof

Additional data also documented an association between BDNF and cognitive decline in PD patients, and it was hypothesized that a reduction in BDNF was associated with cognitive decline in PD patients (Wang Y

doi: 10.1080/14737175.2018.1427066 224 KobowKJeskeIHildebrandtMHaukeJHahnenEBusleiRet al

118 Nonetheless, many studies demonstrated clasmatodendrosis as an outcome of pathologies, which occur in the pre-mortem tissue

The His6-SUMO tag was cleaved by ULP1 treatment, and the tag-free protein was fractioned with Ni-NTA column and Superdex 75size exclusion column (GE Healthcare) with 25 mM HEPES (pH 8.0), 300 mM NaCl, and 1% glycerol