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The reduction in hepatic GSH after a therapeutic dose is minor, but a 15 g dose almost completely depletes hepatic GSH between 2 and 10 hours

To explore upstream regulatory mechanisms, we identified all significantly expressed transcription factors (TFs) across exposures and brain regions in a sex-wise manner using GeneCard annotations (Figs

Despite the lack of enough clinical data on the effectiveness of PPs in preventing AFs consequences, the available data displayed that PPs showed a heterogenous biological activities in preventing the side effects of AFs by targeting several different molecular receptors