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[cited 2020 Jan 27]

2 Ferroptosis in OA: molecular mechanisms and pathological significance 2.1 Ferroptosis in OA pathogenesis: emerging connections Characterized by iron dysregulation and lipid peroxide overload, ferroptosisoriginally triggered by the small molecule erastinwas formally defined in 2012 by Dixons seminal work (Yang J

Subsequent mutational analysis of a Drosophila GPx ( Dm GPx) also suggests a function for a conserved Asn residue that is necessary for the enzymatic function of the GPxs (361)

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