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Studies show the peptide markedly decreases activation of astrocytes and microgliathe brain's primary immune cells whose chronic activation contributes to neurodegeneration

doi: 10.1186/s12916-023-02881-z 71 ReisFMDMonteiro C deSCarneiroMM

When used in combination with orthotics as part of orthotic rehabilitation, it can help to expedite a faster return to activity and improve outcomes

FOXO4-DRI selectively removed senescent cells and has shown benefits in alleviating age-related symptoms in animal models, including hypogonadism, skin phenotypes, fur density, and renal function

As such, NRF2 regulation of these metabolic cascades can have significant implications on cellular metabolism, function, and survival