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In ALD models, except increased iron accumulation, hallmarks of lipid peroxidation like CD36, acyl-CoA synthetase long-chain family member 6(ACSL4), Malondialdehyde, and the depletion of glutathione (GSH) and glutathione peroxidase 4 (GPX4) were observed in the disease process, indicating the critical role of ferroptosis in ALD [16, 68, 69]

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For certain conditions, like knee osteoarthritis, having more than one PRP injection often leads to better and longer-lasting results

found that in senescent macrophages, mtDNA leakage promoted the cGAS-STING inflammatory pathway, and decreased PINK1/Parkin mediated mitophagy

doi: 10.3390/cells12050749