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It is challenging to draw robust conclusions because of the wide range of roles played by the microbiome, the variety of microorganisms that are there, and the numerous variables that can affect their activity

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Soluble urate does not simply appear to behave as an inert end product of purine metabolism [5, 6]

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These mitochondria are primarily located in the myelin-free axons of RGCs and the inner segments of photoreceptors, fulfilling a crucial role in normal energy transportation (140)