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The LC separation was done using the SeQuant Zic-pHilic (150 2.1 mm) with the SeQuant guard column (20 2.1 mm, Merck)

The patients history of optic neuritis, characterized by acute unilateral vision loss, severe eye pain with movement, and field defects documented on visual field testing, is a notable clinical feature

In another systematic review and meta-analysis of 12 studies, it was shown that TENS improved pain relief in participants with diabetic neuropathy, and the improvement was significantly better than in the placebo group

Most data comes from animal studies, a few human special-case studies, and anecdotal evidence