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have demonstrated that HIF-1 directly binds the MDR1 promoter and promotes MDR1 expression, as confirmed with ChIP assays 41

Guerrero et al

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For example, the surveyed incidence of self-reported ethanol-induced flushing reactions in Scandinavians living in Copenhagen as well as Australians of European descent is about 16% in individuals homozygous for the "normal" ADH1B gene but runs to ~23% in individuals with the ADH1-Arg48His SNP variant