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Metabolites that were bridged by one or two reaction steps were defined as reaction pairs (RPs)

Toxicol Appl Pharmacol 159:175184 Aravindakumar CT, Ceulemans J, De Ley M (1999) Nitric oxide induces Zn 2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiol

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Some of the key post-registration obligations and reporting requirements include: Change notification: If you make any changes to your medical device, you must notify HSA within 30 days of the change