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In colorectal cancer cells with mutant KRAS, SLC25A22-Mediated Glutaminolysis reduces DNA demethylation to increase WNT Signaling, Stemness, and drug resistance

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In addition to these metabolic functions, NAD + emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, [46] [47] and can therefore have important extracellular roles

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Notably, they were localised to the same zone as the TUNEL positive cells and contained one or more DAPI positive nuclei in their processes which were clearly separate from the nucleus of the host cell demonstrating engagement in the uptake of neighbouring apoptotic cells