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It is not fair to demonize Metformin over this issue

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Cell homing detection PC12 cells (2 10 4 cells per well) were seeded in the upper chambers of the transwell nest, while different concentration of FSZ-GelMA hydorgel were fixed in bottom of the upper chambers with visible light source

Thus, the absence of metastasis in the triple therapy group may be partially due to the loss of cancer cells (secondary to the cytotoxic effect of gemcitabine) and the decreased stemness of the surviving cells due to HGF/c-MET inhibition