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Bioavailability varies significantly depending on preparation, presence of the activating enzyme, heat exposure, and individual gut and metabolic differences

You want to fix the damage and address the underlying cause(s) of that damage

On the other hand, sulbutiamine is a cofactor of an enzyme that is crucial for the production of GABA the main inhibitory neurotransmitter capable of lowering stress levels

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*Clinical response=reduction in complete Mayo score of 3 points and 30% from baseline with an accompanying decrease in rectal bleeding subscore of 1 point or absolute rectal bleeding subscore of 1 point