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Description

In ovarian, 216 prostate and pancreatic cancers, NAPRT has been found upregulated just like NAMPT gene

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Upon IGF-1 binding, IGF-1R undergoes autophosphorylation, activating downstream signaling pathways such as PI3K/AKT and MAPK that promote cell proliferation and differentiation while inhibiting apoptosis (Figure 1) [16]