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27,28 Additional advantages of PHIs include ease of administration (oral dosing, especially advantageous in patients not on dialysis or who are on home hemodialysis), cheaper manufacturing with less stringent transportation logistics (ESAs need to be kept refrigerated), 55 and less immunogenicity (a concern with ESAs), given that they are not protein-based

Mossmann, D., Park, S

The driving forces for this reaction are the nucleotide ratios and low proton motive force, which promotes protonation of H664 from the matrix side

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