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A wide range of non-motor manifestations, including hyposmia or anosmia, gastrointestinal disturbances like chronic constipation, rapid eye movement (REM) sleep behavior disorder, autonomic dysfunction, mood changes like depression and anxiety, and progressive cognitive impairment, account for a significant portion of the disease burden [3]

In vivo ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimers disease, Parkinsons disease, and diabetes

Phytomedicine 114 , 154792 (2023)

However, CSE exposure did not significantly affect the response, resulting in very similar IC 50 values (63.6 5.1 M without and 63.9 4.4 M with CSE

Obesity: Global epidemiology and pathogenesis