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Critical Reviews in Clinical Laboratory Sciences

10.1016/j.jinorgbio.2015.09.003 58 SteinbrennerH.SiesH

However, there are several limitations

Future studies on the role of oxidative stress in the comorbidity of both diseases should further clarify the nature of these processes, identify common mechanisms involved in the course of diseases, and consider the role of antioxidants in the development of therapeutic strategies

In cardiometabolic contexts such as DM2 and HTN, agents like SGLT2 inhibitors and AMPK/Sirtuin modulators illustrate how metabolic correction can dovetail with oxidative protection