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For example, catalpol attenuates depression-like behaviour in pathological hyperglycaemic states, and its antidepressant mechanism is attributed to the upregulation of PI3K/AKT/Nrf2/HO-1 signalling pathway by reversing the abnormal phosphorylation of PI3K and Akt, as well as the abnormal levels of Nrf2 protein, HO-1 and superoxide dismutase, glutathione peroxidase, glutathione transferase, and reducing glutathione (Zhao et al., 2012)

Read our Research The science of Glutathione Glutathione (GSH) is one of the brains most important antioxidants

The number of Cys residues in the CSD motif was mapped onto the phylograms manually

Cell Death Dis 15 , 534 (2024)

Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes