glutathione pathway breast cancer

glutathione pathway breast cancer metabolism in progression and treatment resistance Glutathione depletion and dihydroorotate dehydrogenase

Name: glutathione pathway breast cancer metabolism in progression and treatment resistance Glutathione depletion and dihydroorotate dehydrogenase
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Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis augment to surmount triple negative breast cancer ScienceDirect Role of Glutathione in Cancer: From Mechanisms to Therapies MitoWorld Metabolic Regulation of Ferroptosis in Breast Cancer Decoding ferroptosis for cancer therapy Nature Reviews Cancer

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The authors proposed that SFN could be administered as an adjunct to chemotherapy to reduce side effects [72]

doi: 10.1096/fj.02-0508fje 48 NuttallS

Hyperactivation of macrophages and intense secretion of pro-inflammatory cytokines lead to increased pulmonary edema that reduces the gas diffusion in the alveoli leading to hypoxia and in severe cases, respiratory failure (Moldoveanu et al., 2009