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Some of the common signs of vitamin B12 deficiency in skin and nails include: Pale or dull complexion Pigmentation or uneven tone Hair thinning and slow growth Weak, brittle, or bluish nails Tingling in hands or feet If you notice these changes, its worth checking your B12 levels

Combination data with diet suggest complementary mechanisms, and reviews highlight continued medicinal-chemistry work to tune potency, selectivity, and exposure for future translational studies

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13 Another study, comparing oral and sublingual administration of a complex of B12, folate and vitamin B6 also found no significant differences in effect on homocysteine between the two modes of administration