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Dose-limiting adverse events are likely due to low selectivity and inhibition of other glutamine-utilizing enzymes, such as amidotransferases and glutamine synthetase

However, dysregulation of this process, leading to excessive or persistent senescence, is associated with adverse reproductive outcomes

FIGURE 1 This synthesis protocol leverages the coupling reaction of FA with graphene oxide through a phenylboronic acid derivative, an approach similar to that described by Li et al

Overall, there is still a lack of convincing evidence for the clinical efficacy of functional food actives, and large-scale, high-quality RCTs are urgently needed to facilitate the translation of these actives from the laboratory to clinical applications

Medical-grade equipment and sterile technique ensure safety