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This is true for conditions like anesthesia the The ICD-10 system is a big step up from ICD-9

Lenton in the context of environmental systems defines tipping points as conditions or situations, where a small perturbation triggers a large response

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Moreover, case reports in patients with small intestinal bacterial overgrowth further support a microbial contribution to elevated MMA: in such individuals, broad-spectrum antibiotics normalized MMA levels, suggesting that gut bacteria capable of producing propionateand potentially MMA itselfcan significantly elevate systemic concentrations (Tejero et al