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10.1016/j.ecoenv.2018.08.050 48 RajagopalanS.Al-KindiS

Studies indicate that the inhibition of DHODH results in a reduction of CoQH2 levels, which elevates ROS production and subsequently triggers ferroptosis

These findings suggest that ESC may alleviate experimental DN-associated cognitive impairment through modulation of the MAPK signaling pathway, exerting both antioxidative and anti-inflammatory effects

doi: 10.3390/ijms20174279 129 SaunierEAntonioSRegazzettiAAuzeilNLaprvoteOShayJWet al

Dose Progression Pathway After at least 4+ weeks at 12.5 mg, you may progress to: 12.5 mg stay on this current dose 15 mg the maximum therapeutic dose Your titration is customized based on tolerance, goals, and progress